Center Of Public Health-Tetovo is one of the oldest health institution in Republic of Macedonia and an extension of the regional hygiene institution established in 1957.

It has conducted with success activities till 1965, when became part of the Medical Center-Tetovo, as Hygiene Epidemiological Agency. With reorganization of the health activity in Republic of Macedonia in 1994, the health care institute – Tetovo is established again, as complete organizational and independent health organizational, which from December 2009 is renamed accordance with the Health Care Law no.67/29 May 2009.